Twig & Leaf Wellness


Frequently Asked Questions 


What is MSM? Methylsulfonylmethane, better known as MSM, is a naturally occurring compound found in plants, animals and humans. MSM supplies amino acids, the building blocks of proteins, with sulfur, the third most abundant mineral in the body. Sulfur is essential for the healthy formation and repair of connective tissue like cartilage, collagen and keratin.


MSM is an important nutrient for the maintenance of healthy joints, tendons, ligaments and other connective tissue. It aids the immune system via supporting a healthy inflammatory response and is essential to glutathione production, a key antioxidant in the body. Sufficient glutathione levels are vital for a healthy, functioning immune system. 


MSM is known as the "beauty mineral" because it helps keep hair, skin and nails healthy and strong by boosting the production of collagen and keratin. MSM also supplies hair follicles with sulfur, an ingredient vital to the production of cysteine and methionine, sulfur dependent amino acids in hair responsible for its strength, texture and resilience. Some speculate that MSM may help boost growth by extending the growing phase of hair.


MSM is a popular ingredient in hair and nail growth, skin care and joint health supplements because of these reasons but is also highly effective when used alone. MSM and Vitamin C may work synergistically to enhance the bioavailability of each for optimal results. Our MSM products deliver concentrated, therapeutic doses to help support:

• Longer, Stronger Hair and Nails 
• Healthy Skin & Collagen Production 
• Healthy Joints & Exercise Recovery
• Immune Health


How long will it take to ship my order? Orders typically ship within 1-3 business days after order placement barring out of stock products and extenuating circumstances. Please allow 2-7 business days to receive your order. 


What is your phone number? Can I place a phone order? Currently, all inquiries are handled through email. If you have any question that is not answered here, please feel free to email us at or contact us through our chat feature on the bottom right of the website.


Are Twig & Leaf products made in the US? Yes, Twig & Leaf products are made in the U.S. in FDA registered and GMP-compliant facilities.


What type of MSM do you use? We use OptiMSM® which undergoes a multi-stage distillation process to remove impurities and isolate the MSM molecule, resulting in a highly consistent, 99.9% pure product. OptiMSM® is the only GRAS-designated MSM on the market. GRAS (“generally recognized as safe”) is the designation given by the FDA to substances considered safe for direct or indirect addition to food. OptiMSM® is the only MSM made in the U.S. and has earned the reputation for being the purest, safest and most consistent MSM in the world. OptiMSM® is Kosher and Halal certified, non-GMO, gluten-free, allergen-free, non-shellfish-derived and vegan.


Are your MSM products bitter tasting? We love the health giving properties of MSM but hated the bitter powders and hard to swallow pills so we carefully formulated our MSM products to not only be highly potent but also taste great using  natural sweeteners and flavors. 


How much MSM can I take in one day? The therapeutic dose for MSM is 1,000 mg but doses as high as 3,000 mgs can be safely taken with minimal side effects.


How long does it take to see results? Depending on why you're taking it, you may begin to notice results within 1-4 months of daily use, but individual results will vary.


Are your products allergen-free? Twig & Leaf products may be made in a facility that processes egg, dairy, fish, shellfish, soy, wheat, peanuts and tree nuts. 


Is your MSM marine derived? Our MSM products contain OptiMSM which is non-shellfish derived. 


Can I add your MSM products to dairy based beverages, soda (carbonated beverages) or alcohol? We do not recommend that you add our products to dairy or carbonated beverages as they may decrease the effectiveness of MSM. Do not add our products to any product that contains alcohol.


Can I give your products to my children or pets? Twig & Leaf products are formulated for adult human usage only, age 18 and over. 


Can I use these products as eye drops? Twig & Leaf products are for oral consumption only. 


Can pregnant or lactating women take your products? As with any vitamin or supplement, if you are pregnant or lactating, consult a qualified health care professional before using. 


Is it safe to take MSM if you have an allergy to sulfa drugs? Yes. There have been no verifiable cases of an allergic reaction to MSM including through pathways similar to sulfa-drugs. Although both contain sulfur, that is where their similarities end.  Sulfa-drugs contain a chemical group called sulfonamide, which generally are the cause of allergic reactions as they metabolize, and specific side chains are released. The allergy-causing compounds bear no resemblance structurally or functionally to MSM. However, if you have a medical condition or take medication, always consult with a qualified health care professional before using any vitamin or supplement.  


Does MSM have side effects? MSM is considered safe and is generally well tolerated with minimal side effects. However, a small number of people may experience mild gastrointestinal discomfort. To mitigate this, start out with a quarter or half of the recommended daily dose during the first couple of days and gradually work your way up to the full dose as your body adjusts. If you are on blood thinners, you should not take MSM. As with any vitamin or supplement, if you have or suspect that you have a medical condition or take medication, always consult with a qualified health care professional before using.  


Twig & Leaf products contain OptiMSM which is the only brand of MSM on the market today that has (GRAS) designation by the FDA.